Inducible Gene Expression System
Permits In Vivo and In Vitro Research of Toxic Proteins

The MERLIN^® Custom Services division of Qbiogene has introduced a novel inducible gene expression system that enables scientists to study the effects of toxic proteins in vitro and in vivo. The Q-Mate™ Inducible Expression System uses a molecular expression control system that allows researchers to turn expression of the toxic protein off, infect the target cell with the gene of interest, and then turn gene expression back on to study the effects and function of the protein that is expressed.

The Q-Mate Expression System is based on the regulatory gene CymR, which controls the transformation of p-cymene to cumate and the further degradation of the cumate molecule in Pseudomonas putida F1. A recombinant Adenovirus is used to carry the gene of interest and infect the target cell. The system was developed by a group of scientists led by Dr. Bernard Massie at the Biology Research Institute in Montreal, Quebec, Canada and Qbiogene’s scientific staff. Qbiogene holds the exclusive license to this technology.

As with all Qbiogene Custom Services, the new Q-Mate Inducible Expression System is competitively priced, available immediately, and backed by comprehensive technical support. For more information, visit the Qbiogene website at: www.qbiogene.com, e-mail adenovirus@qbiogene.com, call toll-free at 1-888-362-5487, or write Qbiogene, Inc., 1801 de Maisonneuve Blvd, Suite 800, Montreal, Quebec, H2H 1J9 Canada.