Selected references to Qbiogene’s Adenoviral products

Adenoviral vector systems

Bhat, R.V., J. Shanley, et al. (2000). Regulation and localization of tyrosine 216 phosphorylation of clycogen synthase kinase-3b in cellular and animal modes of neuronal degeneration. Proc Natl Acad Sci USA 97 (20):11074-11079. (AdEasy™)

Bhattacharya, D., et al. (2002). Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries. Proc Natl Acad Sci 99(13):8838-8843. (Adeno-Quest™)

Chiba, N., Parvin, J.D. (2001). Redistribution of BRCA1 among four different protein complexes following replication blockage. J of Biol Chem. 276(42):38549-38554. (AdEasy™)

Chou, T.T., Trojanowski, J.Q., Lee, V.M-Y. (2000). A novel apoptotic pathway induced by nerve growth factor-mediated TrkA activation in medulloblastoma. J of Biol Chem. 275(1):565-570. (Adeno-Quest™)

Dmitriev, I., et al. (2000). Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth mediates adenovirus targeting to epidermal growth factor receptor-positive cells. J Virol. 74(15):6875-6884. (Adeno-Quest™)

Dumon, K.R., et al. (2001) FHIT gene therapy prevents tumor development in Fhit-deficient mice. Proc Natl Acad Sci USA 98(6):3346-3351. (adenoviral backbone vector)

Filipova, N., Sedelnikova, A., Tyler, W.J., Whitworth, TL., Fortinberry, H., Weiss, DS. (2001). Recombinant GABAC receptors expressed in rat hippocampal neurons after infection with an adenovirus containing the human r1 subunit. Journal of Phys 535.1:145-153. (Adeno-Quest™)

Galanis, E., Bateman, A., Johnson, K., Diaz, R.M., James, C.D., Vile, R., Russell, S.J. (2001). Use of viral fusogenic membrane glycoproteins as novel therapeutic transgenes in gliomas. Human Gene Ther 12:811-821. (Adeno-Quest™)

Gilbertson, D.G., et al. (2001). Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF a and b receptor. J of Biol Chem. 276(29):27406-27414. (AdEasy™)

Gurnell, M., et al. (2000). A dominant-negative peroxisome proliferator-activated receptor g (PPARg) mutant is a constitutive repressor and inhibits PPARg-mediated adipogenesis. J of Biol Chem. 275(8):5754-5759. (Adeno-Quest™)

Hattori K., et al. (2001). Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopiesis by recruitment of vasculogenic and hematopoietic stem cells. J. Exp. Med. 193(9):1005-1014. (Adeno-Quest™)

Hayashi, M., et al. (2001). BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase. J of Biol Chem. 276(12):8631-8634. (AdEasy™)

Heikkila, P., Tibell, A., Morita, T., Chen, Y., Wu, G., Sado, Y., Ninomiya, Y., Pettersson, E., Tryggvason, K. (2001). Adenovirus-mediated transfer of type IV collagen a5 chain cDNA into swine kidney in vivo: deposition of the protein into the glomerular basement membrane. Gene Ther 8:882-890. (Adeno-Quest™)

Hoek, R.M. et al. (2000). Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290:1768-1771. (Adeno-Quest™)

Korhonen, J., Said, F.A., Wong, A.J., Kaplan, D.R. (1999) Gab1 mediates neurite outgrowth, DNA synthesis, and survival in PC12 cells. J of Biol Chem. 274(52):37307-37314. (Adeno-Quest™)

Kuehel, D.G., et al. (2000). Adenovirus-mediated human pancreatic lipase gene transfer to rat bile: gene therapy of fat malabsorption. Am J Physiol Gastrointest Liver Physiol 279:G1031-G1036. (Adeno-Quest™)

Lee, H-J., et al. (2001) Formation and removal of a-Synuclein aggregates in cells exposed to mitochondrial inhibitors. J of Biol Chem. In Press. (Adeno-Quest™)

Liang, Y., Medhekar, R., Brockman, H.L., Quinn, D.M., Hui, D.Y. (2000). Importance of Arginines 63 and 423 in modulating the bile salt-dependant and bile salt-independent hydrolytic activities of rat carboxyl ester lipase. J of BiolChem. 275(31):24040-24046. (Adeno-Quest™)

Majumdar, A.S., Hughes, D.E., Lichtsteiner, S.P., Wang, Z., Lebkowski, J.S., Vasserot, A.P. (2001). The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters. Gene Ther 8:568-578. (Adeno-Quest™)

Mazzoni, I.E., et al. (1999). Ras regulates sympathetic neuron survival by suppressing the p53 cell death pathway. J Neuroscience 19(22):9716-9727. (Adeno-Quest™)

Nagarajan, R., Svaren, J., Le, N., Araki, T., Watson, M., Milbrandt, J. (2001). EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression. Neuron 30:355-368. (Used the procedure for the TCID50 method from the applications manual of Qbiogene’s AdEasy™ kit.)

Pilotte, J., et al. (2001) Nuclear translocation controlled by alternatively spliced isoforms inactivates the QUAKING apoptotic inducer. Genes Dev 15:845-858. (AdEasy™)

Rehm, A., et al. (2002). Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells. J Virol 76(10):5043-5050. (Adeno-Quest™)

Roux, Ph.P., et al. (2001). The p75 neurotrophin receptor activates Akt (protein kinase B) through a phophatydilisonitol 3-kinase-dependant pathway. J of Biol Chem. 276(25):23097-23104. (Replication-defective adenoviral DNA)

Ruest, L-B., Marcotte, R., Wang, E. (2001). Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes, and its protective effect against caspase-3-mediated apoptosis. J of Biol Chem. In Press. (Adeno-Quest™)

Sheff, D.R., et al. (2002) Actin dependence of polarized receptor recycling in Madin-Darby canine kidney cell endosomes. Mol Biol Cell 13:262-275. (AdEasy™)

Stewart, A. et al. (2002). Enzymatic properties of human cytosolic phospholipase A2g. J Biol Chem In Press. (AdEasy™)

Thule, P.M., Liu, J., Phillips, LS. (2000). Glucose regulated production of human insulin in rat hepatocytes. Gene Ther 7(3):205-214. (Adeno-Quest™)

Thule, P.M., Liu, J-M. (2000). Regulated hepatic insulin gene therapy of STZ-diabetic rats. Gene Ther. 7:1744-1752. (Adeno-Quest™)

Tureckova, J., Wilson, E.M., Cappalonga, J.L., Rotwein, P. (2001). Insulin-like growth factor-mediated muscle differentiation. (Collaboration between phosphatidylinositol 3-kinase-Akt-signaling parthways and myogenin.) J of Biol Chem. 276(42):39264-39270. (AdEasy™)

Wagner, K-U., et al. (1997). Cre-mediated gene deletion in the mammary gland. Nucleic Acids Research 25(21): 4323-4330. (Used Qbiogene’s protocol to propagate viral particles.)

Yu, S., et al. (2001). Human Peroxisome proliferator-activated receptor a (PPARa) supports the induction of peroxisome proliferation in PPARa-deficient mouse liver. J Biol Chem. 276(45):42485-42491. (AdEasy™)

AdenoExpress™ Vectors

Aurisicchio, L. et al. (2000). Liver-specific alpha 2 interferon gene expression results in protection from induced hepatitis. J Virol. 74(10) :4816-4823. (Ad5.CMV-GFP)

Borgland, S.L., et al. (2000). Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-KB. J Virol. 74(9):3941-3947. (Ad5.CMV-LacZ)

Doukas, J., et al. (1999). Retargeted delivery of adenoviral vectors through fibroblast growth factor receptors involves unique cellular pathways. FASEB J. 13 :1459-1466.

Hoganson, D.K., Sosnowski, B. A. et al. (2001). Uptake of adenoviral vectors via fibroblast growth factor receptors involves intracellular pathways that differ from the targeting ligand. Molecular Therapy 3(1):105-112.

Kitazono, M. et al. (2001). Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228. Cancer Res 61:6328-6330. (Ad5.CMV-LacZ)

Medina, D., et al. (1999). Adenovirus-mediaed cytotoxicity of chronic lymphocytic leukemia cells. Blood. 94(10):3499-3508. (Ad5.CMV-GFP)

Muruve, D.A., et al. (1999). Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo. Human Gene Ther 10:956-976. (Ad5.CMV-GFP)

Nagata, D., et al. (2001). Transcriptional activation of the cyclin D1 gene is mediated by multiple cis-elements, including SP1 sites and a cAMP-responsive element in vascular endothelial cells. J of Biol Chem. 276(1):662-669. (Ad5.CMV-GFP)

Nishimatsu, H., et al. (2001). Adrenomedullin Induces Endothelium-Dependent Vasorelaxation via the Phosphatidylinositol 3-Kinase/Akt–Dependent Pathway in Rat Aorta. Circ. Res. 89:63-70 (Ad5CMV-GFP)

Nyberg-Hoffman, C., Aguilar-Cordova, E. (1999). Instability of adenoviral vectors during transport and its implication for clinical studies. Nat Med 5(8):955-957. (Ad5.CMV-GFP)

Pickles, R.J., et al. (2000). Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized cells reveals the glycocalyx as a barrier to adenovirus–mediated gene transfer. J Virol. 74(13):6050-6057. (Ad5.CMV-GFP)

Regn, S., Raffegerst, S., Chen, X., Schendel, D., Kolb, H-J. and Roskrow, M. (2001). Ex vivo generation of cytotoxic T lymphocytes specific for one or two distinct viruses for the prophylaxis of patients receiving an allogeneic bone marrow transplant. Bone Marrow Transplant 27:53-64. (Ad5.CMV-GFP, Ad5.CMV-Null)

Scala, S., Portella, G. et al. (2000). Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias. Proc Natl Acad Sci USA 97 (8):4256-4261. (AdCMV-LacZ)

Smith, J.S., Keller, J.R. et al. (1999). Redirected infection of directly biotinylated recombinant adenovirus vectors through cell surface receptors and antigens. Proc Natl Acad Sci USA 96:8855-8860.

Somasundaram, K. et al. (1999). BRCA1 signals ARF-dependent stabilization and co-activation of p53. Oncogene 18:6605-6614.

Stewart, A. et al. (2002). Enzymatic properties of human cytosolic phospholipase A2g. J Biol Chem In Press.

Toma, J.G., et al. (2000). Evidence that helix-loop-helix proteins collaborate with retinoblastoma tumor suppresor protein to regulate cortical neurogenesis. J Neuroscience 20(20):7648-7656. (Ad5.CMV-GFP)

Twisk, J., et al. (2000). The role of the LDL receptor in apolipoprotein B secretion. J Clin Invest. 105(4):521-532. (Ad5.CMV-LacZ)

Varda-Bloom, N., Shaish, A., Gonen, A., Levanon, K., Greenbereger, S., Ferber, S., Levkovitz, H., Castel, D., Goldberg, I., Afek, A., Kopolovitc, Y., Harats, D. (2001). Tissue-specific gene therapy directed to tumor angiogenesis. Gene Ther 8:819-827.

Viollet, B., et al. (2001). Embryonic but not postnatal reexpression of hepatocyte nuclear factor 1a (HNF1a) can reactivate the silent phenylalanine hydroxylase gene in HNF1a-deficient hepatocytes. Mol Cell Biol. 21(11):3662-3670. (Ad5.CMV-GFP)

Vollrath, D., Feng, W., Duncan, J.L., Yasumura, D., D’Cruz, P.M., Chappelow, A., Matthes, M.T., Kay, M.A., and LaVail, M.M. (2001). Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk. Proc Natl Acad Sci USA 98(22):12584-12589. (Ad5.CMV-GFP)

Whitfield, J., Neame, S.J., Paquet, L., Bernard, O., Ham, J. (2001). Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and exhibiting mitochondrial cytochrome c release. Neuron 29:629-643. (Ad5.CMV-LacZ)

Yang, M., Baranov, E. et al. (2000). Visualizing gene expression by whole-body fluorescence imaging. Proc Natl Acad Sci USA 97(22):12278-12282. (Ad5.CMV5-GFP)

Custom Adenovirus Services

Bhattacharya, D., et al. (2002). Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries. Proc Natl Acad Sci 99(13):8838-8843.

Zhong, L., Granelli-Piperno, A. et al. (1999). Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells. Eur J Immunol 29(3):964-72.

BJ5183 EC cells

Nakamura, N., Ramaswamy, S., Vasquez, F., Signoretti, S., Loda, M., Sellers, W. (2000). Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol and Cell Biol 20(23):8969-8982.

QBI-HEK 293A Cells

Bastaki, M, et al. (2002). Absence of direct delivery for single transmembrane apical proteins or their “secretory” forms in polarized hepatic cells. Mol Biol Cell 13:225-237.

Bhattacharya, D., et al. (2002). Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries. Proc Natl Acad Sci 99(13):8838-8843.

Griffiths, L., Binley, K., Iqball, S., Kan, O., Maxwell, P., Ratcliffe, P., Lewis, C., Harris, A., Kingsman, S., Naylor, S. (2000). The macrophage – a novel system to deliver gene therapy to pathological hypoxia. Gene Ther 7(3):255-262.

Lin, A.H., Kasahara, N., Wu, W., Stripecke, R., Empig, C.L., Anderson, W.F., Cannon, P.M. (2001). Receptor-specific targeting mediated by the coexpressin of a targeted murine leukemia virus envelope protein and a binding-defective influenza hemagglutinin protein. Human Gene Ther 12:323-332.

Miao, R.Q., Murakami, H., Song, Q., Chao, L., Chao, J. (2000). Kallistatin stimulates vascular smooth muscle cell proliferation and migration in vitro and neointima formation in balloon-injured rat artery. Circ Res. 86:418-424.

Soifer, H., Higo, C., Kzazian, H.H., Moran, J.V., Mitani, K., Kasahara N. (2001). Stable integration of transgenes delivered by a retroposon-adenovirus hybrid vector. Human Gene Ther 12:1417-1428.

Stewart, A. et al. (2002). Enzymatic properties of human cytosolic phospholipase A2g. J Biol Chem In Press.

Whitfield, J., Neame, S.J., Paquet, L., Bernard, O., Ham, J. (2001). Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and exhibiting mitochondrial cytochrome c release. Neuron 29:629-643.

Zhang, J., Yoshida, H., Chao, L., Chao, J. (2000). Human adrenomedullin gene delivery protects against cardiac hypertrophy, fibrosis, and renal damage in hypertensive Dahl salt-sensitive rats. Human Gene Ther 11:1817-1827.