Novel Baculovirus System Now Available in North America

Qbiogene’s MERLIN® Custom Service Division has recently made available the BacTen™ Baculovirus System for the production of recombinant proteins. This novel system utilizes the p10 promoter from the Autographa californica Nuclear polyhedrosis virus (AcMNPV), which has a number of advantages over the more common polyhedrin promoter. These advantages include the earlier initiation of expression for some recombinant proteins since the p10 promoter has been shown to be activated earlier in infection time course than the polyhedrin promoter. As the polyhedrin gene expression is abolished, the foreign gene expression driven by the p10 promoter is placed in a favorable context for optimal production of the recombinant protein. In BacTen™ based recombinants, no P10 polypeptide is produced. This delays the lysis of infected cells and allows a greater cumulative expression of recombinant proteins.

This addition to our Custom Baculovirus Services includes every step in the production of a recombinant protein, starting with sub-cloning the gene of interest and construction of the recombinant virus, through large-scale production of the recombinant protein in serum-free medium.

As a division of Qbiogene, MERLIN® Custom Services embody a collection of technological expertise and high-capacity production facilities that guarantee to provide the highest quality research services in the shortest possible time. These services include Adenovirus Production, displayPROFILE™ Expression Profiling, Peptide Synthesis, Antibody Production, DNA and Protein Sequencing, and Baculovirus and Mammalian Based Protein Production.

If you would like to have more information on our MERLIN® Custom Baculovirus Services, contact our Baculovirus Team at 1-888-DNA-KITS or email us at baculovirus@qbiogene.com.