Alterations of the HER-2/neu proto-oncogene have been implicated in the carcinogenesis and prognosis of breast cancer. The HER-2/neu (also called ERBB2) gene encodes a 185 kDa transmembrane cell surface glycoprotein and is a member of the tyrosine kinase family with a high degree of homology to the epidermal growth factor (EGF-R). Amplification of HER-2/neu has also been reported in prostate carcinoma, uterus endometrial cancer and primary gastric cancer.
The new developed
Qbiogene probe for HER-2/neu, labeled with Rhodamine (red), uses the Universal Linkage System (ULS®)
and is optimized to detect amplification of the HER-2/neu gene region.
The included Chromosome 17 Alpha-Satellite probe, labeled with FITC (green), serves as internal control
and simultaneously defines the ploidy status of Chromosome 17.
Description of the HER-2/neu probe in PDF format - Click here
Description of the N-myc/Alphasat. 2 probe cocktail and the 1p36 probe