Peptide Coupling Reagents

	Each components is purified to meet stringent specifications. Minor impurities known to affect synthesis yield are eliminated through chemical and physical treatment.
	Water content minimized. Bottles are filled under inert atmosphere to ensure maximum shelf-life.
	All solutions are filtered through 0.2 mm filters.
	Ready-made reagents bottled directly for application on semi-automatic or automatic peptide synthesizers.
	Bulk reagents available as a special order

READISSOLV™ Packages

Economical and practical, these reagents are ready-to-use in automatic peptide synthesizers. No fume hood required! All reagents are available at molar concentration most commonly used. To prepare READISSOLV™ reagents, simply mix chemicals in the stoppered glass bottles provided.

Product Specifications

HBTU - Peptide Synthesis Grade

O-(1H-benzotriazole-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate
C₁₁H₁₆F₆N₅OP     M.W. 379.25     CAS: 94790-37-1

Appearance	White to off-white microcrystalline powder *
Melting Point	Greater than 200°C **
Solubility	10% acetonitrile / 10% DMF - clear and transparent
Loss on Drying	less than 0.5%
Identification	FTIR spectrum conforms to standard
Assay	HPLC greater than 98%
* The product should be stored in the dark to avoid formation of a yellow coloration
** The melting point is very sensitive to the presence of free 1-hydroxybenzotriazol

TBTU - Peptide Synthesis Grade

O-(1H-benzotriazole-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate
C₁₁H₁₆N₅O.BF₄     M.W. 321.1     CAS: 125700-67-6

Appearance	White to off-white microcrystalline powder *
Melting Point	Greater than 200°C **
Solubility	10% acetonitrile / 10% DMF - clear and transparent
Loss on Drying	less than 0.5%
Identification	FTIR spectrum conforms to standard
Assay	HPLC greater than 98%
* The product should be stored in the dark to avoid formation of a yellow coloration
** The melting point is very sensitive to the presence of free 1-hydroxybenzotriazole

HOBt hydrate - Peptide Synthesis Grade

N-Hydroxybenzotriazole Monohydrate
C₆H₅N₃O.H₂0     M.W. 153.1     CAS: 2592-95-2

Appearance	White crystalline powder *
Melting Point	Greater than 155°C **
Water	Minimum of 12%
Assay	HPLC greater than 98%
* The product should be stored in the dark to avoid formation of a yellow coloration

HOBt anhydrous - Peptide Synthesis Grade

N-Hydroxybenzotriazole
C₆H₅N₃O     M.W. 135.1     CAS: 2592-95-2

Appearance	White crystalline powder *
Melting Point	Minimum of 155°C **
Water	Less than 1%
Assay	HPLC greater than 98%
* The product should be stored in the dark to avoid formation of a yellow coloration

Ordering Information